Phenotypes Associated with This Genotype

Genotype
MGI:5549965

• Allelic Composition: b2b2350Clo/b2b2350Clo
• Genetic Background: C57BL/6J-b2b2350Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 2350-007-8 (E13.5) exhibits situs inversus totalis with dextrocardia and inverted outflow

cardiovascular system

right aortic arch ( J:175213 )

double aortic arch ( J:175213 )

abnormal inferior vena cava morphology ( J:175213 )

dual inferior vena cava ( J:175213 )

double outlet right ventricle ( J:175213 )

double outlet right ventricle with atrioventricular septal defect ( J:175213 )

double outlet right ventricle, Taussig bing type ( J:175213 )

dextrocardia ( J:175213 )

superior-inferior ventricles ( J:175213 )

atrioventricular septal defect ( J:175213 )

growth/size/body

kidney cyst ( J:175213 )

heterotaxia ( J:175213 )

left pulmonary isomerism ( J:175213 )

situs inversus totalis ( J:175213 )

renal/urinary system

kidney cyst ( J:175213 )

hydronephrosis ( J:175213 )

respiratory system

left pulmonary isomerism ( J:175213 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kartagener syndrome		DOID:0050144		J:175213
primary ciliary dyskinesia		DOID:9562	OMIM:PS244400	J:175213
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213