Phenotypes Associated with This Genotype

Genotype
MGI:5550582

• Allelic Composition: Tg(PDGFB-APPInd)F17Plhn/0
• Genetic Background: C57BL/6-Tg(PDGFB-APPInd)F17Plhn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:107982 )

• in the passive avoidance test, the latency to enter the dark chamber is similar to controls at 7 months of age, however the post-shock latency is shorter, indicating impaired memory retention

• however, 11-14 months old mutants show normal locomotor activity

impaired spatial learning ( J:107982 )

• in the Morris water maze hidden platform test, mutants show a higher escape latency than controls and in the probe trail, 12.5 month old mutants sow reduced dwelling time in the target quadrant compared to controls

• however performance in the visual platform test is normal

increased anxiety-related response ( J:107982 )

• in the elevated plus maze, 11 month old mutants, but not 5 month old mice, visit the open arm less frequently and spend less time there than controls, suggesting increased anxiety with age

mortality/aging

premature death ( J:107982 )

• 92% of mutants survive until at least 480 days vs. 100% of controls

nervous system

abnormal hippocampus pyramidal cell layer ( J:107982 )

• thickness of anti-NeuN-stained pyramidal layer of the hippocampal CA1 region is reduced

abnormal frontal lobe morphology ( J:107982 )

• cell density of parietal cortex and prefrontal cortex are reduced at 16-18 months

abnormal parietal lobe morphology ( J:107982 )

• cell density of parietal cortex and prefrontal cortex are reduced at 16-18 months

abnormal dendrite morphology ( J:107982 )

• severe atrophy of large apical dendrites of pyramidal neurons in various cortical regions including the prefrontal and parietal cortices at 16-18 months of age

neuron degeneration ( J:107982 )

• neuronal loss is seen at 16-18 months of age but not at 5 months

• however, plaque-like amyloid beta deposition is not seen up to 18 months of age and gliosis is not seen in the cerebral cortices or hippocampal regions at 14-16 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:107982