Phenotypes Associated with This Genotype

Genotype
MGI:5554212

• Allelic Composition: Dnah5^b2b2395Clo/Dnah5^b2b2395Clo
• Genetic Background: C57BL/6J-Dnah5^b2b2395Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 2395-006-LB presents with heterotaxy and dextrocardia with levogastria

cardiovascular system

pulmonary artery hypoplasia ( J:175213 )

dual inferior vena cava ( J:175213 )

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

anomalous pulmonary venous connection ( J:175213 )

right atrial isomerism ( J:175213 )

dextrocardia ( J:175213 )

atrioventricular septal defect ( J:175213 )

growth/size/body

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

short snout ( J:175213 )

heterotaxia ( J:175213 )

right atrial isomerism ( J:175213 )

right-sided stomach ( J:175213 )

left pulmonary isomerism ( J:175213 )

situs inversus totalis ( J:175213 )

craniofacial

micrognathia ( J:175213 )

short snout ( J:175213 )

digestive/alimentary system

right-sided stomach ( J:175213 )

renal/urinary system

duplex kidney ( J:175213 )

respiratory system

immotile respiratory cilia ( J:175213 )

left pulmonary isomerism ( J:175213 )

skeleton

micrognathia ( J:175213 )

cellular

immotile respiratory cilia ( J:175213 )

muscle

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kartagener syndrome		DOID:0050144		J:175213
primary ciliary dyskinesia 3		DOID:0110599	OMIM:608644	J:175213
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213