Analysis Tools
growth/size/body
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• relative overgrowth of incisors
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• impaired growth; skeleton is normal at birth but is smaller at P21
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craniofacial
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• craniofacial morphology is altered
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• relative overgrowth of incisors
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hematopoietic system
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• extensive vacuolization is seen in cultures of bone marrow mesenchymal stroma
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skeleton
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• skeleton is normal at birth but is smaller at P21
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• relative overgrowth of incisors
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• clavicles are 20-25% smaller at P21 than in wild-type, however their shape is normal
• however, pelvic bone shape is normal in newborns and at P21
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• long bones are 20-25% smaller at P21 than in wild-type
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• bone volume fraction, bone surface, trabecular number and connectivity density are reduced to less than 50% of wild-type values
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• lower cortical density of bones
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• femoral cortical thickness is reduced to less than 50% of wild-type values
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• extensive vacuolization is seen in cultures of isolated osteoblasts from calvarial tissue
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• lower trabecular density of bones and reduction in size and density of trabeculae in vertebrae
• trabecular separation is increased more than 3-fold
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limbs/digits/tail
| N |
• mice do not exhibit aplasia or hypoplasia of digits on the front or rear limb
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Yunis-Varon syndrome | DOID:0060589 |
OMIM:216340 |
J:203638 | |
