Phenotypes Associated with This Genotype

Genotype
MGI:5556259

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Smad4^tm2.1Cxd/Smad4^tm2.1Cxd; Tg(Krt1-15-cre/PGR*)22Cot/0
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin tumor incidence ( J:203922 )

• mice rapidly develop skin tumors beginning 1 month after induction with topical application of RU486 to the back of the skin with 100% penetrance

increased skin squamous cell carcinoma incidence ( J:203922 )

• tumors that develop after RU486 induction are well-to-moderately differentiated squamous cell carcinomas with an epidermal lineage or basaloid squamous cell carcinomas of unknown stem cell origin

increased trichoepithelioma incidence ( J:203922 )

• a subset of benign or locally invasive tumors form adjacent to the squamous cell carcinoma precursor lesions, which are of hair follicle (trichoepitheliomas, basaloid squamous cell carcinoma) or sebaceous gland origin (sebaceous adenomas) after induction with topical application of RU486

increased metastatic potential ( J:203922 )

• metastases develop between 8 and 18 weeks after induction with RU486, with 28% of tumor-bearing mice developing lung metastasis and 1 of 18 mice showing lymph node metastasis

increased adenoma incidence ( J:203922 )

• a subset of benign or locally invasive tumors form adjacent to the squamous cell carcinoma precursor lesions, which are of hair follicle (trichoepitheliomas, basaloid squamous cell carcinoma) or sebaceous gland origin (sebaceous adenomas) after induction with topical application of RU486

increased papilloma incidence ( J:203922 )

• a few benign papillomas are seen after induction with topical application of RU486

integument

increased skin tumor incidence ( J:203922 )

• mice rapidly develop skin tumors beginning 1 month after induction with topical application of RU486 to the back of the skin with 100% penetrance

increased skin squamous cell carcinoma incidence ( J:203922 )

• tumors that develop after RU486 induction are well-to-moderately differentiated squamous cell carcinomas with an epidermal lineage or basaloid squamous cell carcinomas of unknown stem cell origin

increased trichoepithelioma incidence ( J:203922 )

• a subset of benign or locally invasive tumors form adjacent to the squamous cell carcinoma precursor lesions, which are of hair follicle (trichoepitheliomas, basaloid squamous cell carcinoma) or sebaceous gland origin (sebaceous adenomas) after induction with topical application of RU486

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
squamous cell carcinoma		DOID:1749		J:203922