behavior/neurological
cellular
• gradual and progressive shortening of telomeres over three generations
• increase in incidence of fragile telomeres in the bone marrow of G3 mice
|
endocrine/exocrine glands
• subset of seminiferous tubules exhibit complete atrophy in 2/10 males from G2 and G3 generations
|
• partial testicular atrophy observed in 2/10 males from G2 and G3 generations
|
hematopoietic system
• mild hyperplasia in the bone marrow is observed in 1/14 mice
|
pancytopenia
(
J:207367
)
• mild pancytopenia affecting all hematopoietic lineages in G2 and G3 generations
|
immune system
• mild hyperplasia in the bone marrow is observed in 1/14 mice
|
• follicular lymphoid hyperplasia is observed in 2/14 mice
|
dermatitis
(
J:207367
)
• skin dermatitis with neutrophilic serocellular crusting is observed in 2/14 mice
|
integument
dermatitis
(
J:207367
)
• skin dermatitis with neutrophilic serocellular crusting is observed in 2/14 mice
|
nervous system
hydrocephaly
(
J:207367
)
• moderate hydrocephalus is observed in 1/14 mice
|
• focal gliosis of white and grey matter in spinal cord is observed in 1/14 mice
|
reproductive system
• subset of seminiferous tubules exhibit complete atrophy in 2/10 males from G2 and G3 generations
|
• partial testicular atrophy observed in 2/10 males from G2 and G3 generations
|
• fertility is diminished over multiple generations of breeding
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
dyskeratosis congenita | DOID:2729 |
OMIM:PS127550 |
J:207367 |