Phenotypes Associated with This Genotype

Genotype
MGI:5558060

cn1

• Allelic Composition: Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds; Tg(Itgax-cre,-EGFP)4097Ach/0
• Genetic Background: B6NTac.Cg-Ifngr1^tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

immune system

decreased interferon-gamma secretion ( J:206257 )

• from NK and NK T cells of mice infected with L. monocytogenes

• however, production in CD8+ T cells is normal

decreased interleukin-12b secretion ( J:206257 )

• reduced from CD8a+ dendritic cells of mice infected with L. monocytogenes

• production from Ly6c+ monocytes is temporarily delayed

increased susceptibility to bacterial infection ( J:206257 )

• mice infected with L. monocytogenes exhibit increased mortality, spleen and liver bacterial counts, reduced IL12b production from CD8a+ dendritic cells compared with control mice

• intravenous L. monocytogenes infection results in reduced bacterial burden

• however, treatment with IL4 neutralizing antibody reduces bacterial burden

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes