Phenotypes Associated with This Genotype

Genotype
MGI:5559052

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:125101 )

• extremity sarcomas in mice injected with Ad-Cre invade adjacent skeletal muscle and uterine sarcomas invade the intestinal wall and pancreas

• 20% of mice with large extremity sarcomas develop metastasis to the lungs

increased sarcoma incidence ( J:125101 , J:155389 )

• 90% of mice injected intramuscularly with an adenovirus expressing Cre recombinase (Ad-Cre) into the extremities develop soft tissue sarcomas after a median time of 3 months (J:125101)

• high penetrance of soft tissue sarcomas also develops after injection of Ad-Cre into the uterus (J:125101)

• soft tissue sarcomas present as large solitary masses originating at the site of Ad-Cre injection, and are high-grade spindle cell neoplasms (J:125101)

• sarcomas show myofibroblastic differentiation with intracytoplasmic filaments with densities (J:125101)

• gene expression analysis indicates that Ad-Cre induced sarcomas are undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma (J:155389)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant fibrous histiocytoma		DOID:1907		J:155389
sarcoma		DOID:1115		J:125101 , J:155389 , J:204376