Phenotypes Associated with This Genotype

Genotype
MGI:5559071

• Allelic Composition: Tmem79^ma/Tmem79^ma
• Genetic Background: involves: C57BL/6JJcl * CBA/CaGr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

impaired skin barrier function ( J:202316 )

• increased transepidermal water loss and lower stratum corneum hydration

dermatitis ( J:202316 )

• spontaneous dermatitis with scratching behavior

• however, dermatitis is rescued by transgenic expression of the wild-type gene

matted coat ( J:202316 )

abnormal epidermis stratum corneum morphology ( J:202316 )

• impaired formation wit less resistance to physical external stress in a tape stripping test

acanthosis ( J:202316 )

• with leukocyte infiltration at 1 week prior to scratching behavior

immune system

dermatitis ( J:202316 )

• spontaneous dermatitis with scratching behavior

• however, dermatitis is rescued by transgenic expression of the wild-type gene

behavior/neurological

excessive scratching ( J:202316 )

• spontaneous dermatitis with scratching behavior

homeostasis/metabolism

impaired skin barrier function ( J:202316 )

• increased transepidermal water loss and lower stratum corneum hydration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:202316