Phenotypes Associated with This Genotype

Genotype
MGI:5559362

cx6

• Allelic Composition: Flg^ft/Flg^ft; Tmem79^ma/Tmem79^ma
• Genetic Background: involves: CBA/CaGr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

impaired skin barrier function ( J:202453 )

• increased transepidermal water loss

skin inflammation ( J:202453 )

• marked skin inflammation with a broad spectrum of pathologies

• some mice exhibit profound lesions and excoriation

abnormal coat appearance ( J:202453 )

alopecia ( J:202453 )

• occasional at 32 weeks of age

brittle hair ( J:202453 )

• hair breakage at 32 weeks of age

• fragile hairs prone to longitudinal splitting and breakage with defective cuticle morphology

matted coat ( J:202453 )

abnormal hair cortex keratinization ( J:202453 )

• keratinization defects

abnormal hair cuticle ( J:202453 )

• defective cuticle morphology

orthokeratosis ( J:202453 )

• prominent, with dermal inflammatory infiltrates

acanthosis ( J:202453 )

• marked

abnormal skin appearance ( J:202453 )

dry skin ( J:202453 )

• significant ichthyosis is seen in neonates

scaly skin ( J:202453 )

• significant ichthyosis is seen in neonates

immune system

increased IgE level ( J:202453 )

blepharitis ( J:202453 )

• occasional blepharitis and eyelid dermatitis in some mice

skin inflammation ( J:202453 )

• marked skin inflammation with a broad spectrum of pathologies

• some mice exhibit profound lesions and excoriation

vision/eye

blepharitis ( J:202453 )

• occasional blepharitis and eyelid dermatitis in some mice

hematopoietic system

increased IgE level ( J:202453 )

homeostasis/metabolism

impaired skin barrier function ( J:202453 )

• increased transepidermal water loss