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Phenotypes Associated with This Genotype
Genotype
MGI:5559449
Allelic
Composition
Tg(Thy1-APPSweAut)A7Tiwa/0
Genetic
Background
Not Specified
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• develop progressive amyloid deposition in cerebral cortices at around 9-12 months of age
• young (4 month) mutants treated with the anti-amyloid beta antibody 266 exhibit increased levels of monomer amyloid beta species in an antibody-bound form, without affecting that of total amyloid beta

homeostasis/metabolism
• develop progressive amyloid deposition in cerebral cortices at around 9-12 months of age
• young (4 month) mutants treated with the anti-amyloid beta antibody 266 exhibit increased levels of monomer amyloid beta species in an antibody-bound form, without affecting that of total amyloid beta

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:204270


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory