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Phenotypes Associated with This Genotype
Genotype
MGI:5559577
Allelic
Composition		 Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.1(Sh3gl1)Lcc mutation (0 available); any Kmt2a mutation (135 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:205605 )
• 50% survival at 6 months

immune system
enlarged spleen ( J:205605 )
• in some mice
myeloid hyperplasia ( J:205605 )
• increased immature myeloid cell population in the bone marrow, spleen and liver
enlarged lymph nodes ( J:205605 )
• in some mice

neoplasm
increased leukemia incidence ( J:205605 )
• acute myeloid leukemia after 12 months in some mice
• however, suppression of Prmt1 reduces leukemic cells

liver/biliary system
enlarged liver ( J:205605 )
• in some mice

hematopoietic system
enlarged spleen ( J:205605 )
• in some mice
myeloid hyperplasia ( J:205605 )
• increased immature myeloid cell population in the bone marrow, spleen and liver

growth/size/body
enlarged liver ( J:205605 )
• in some mice
enlarged spleen ( J:205605 )
• in some mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
leukemia DOID:1240 J:205605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory