Phenotypes Associated with This Genotype

Genotype
MGI:5561116

• Allelic Composition: Cfc1^b2b2736.1Clo/Cfc1^b2b2736.1Clo
• Genetic Background: C57BL/6J-Cfc1^b2b2736.1Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 2736-005-LA shows heterotaxy with dextrocardia, right pulmonary isomerism (4R/4L), and left liver isomerism (2R/2L)

cardiovascular system

abnormal aortic arch morphology ( J:175213 )

vascular ring ( J:175213 )

abnormal right subclavian artery morphology ( J:175213 )

d-loop transposition of the great arteries ( J:175213 )

total anomalous pulmonary venous connection, intracardiac ( J:175213 )

common atrium ( J:175213 )

superior-inferior ventricles ( J:175213 )

atrioventricular septal defect ( J:175213 )

ventricular septal defect ( J:175213 )

muscular ventricular septal defect ( J:175213 )

heart right ventricle hypoplasia ( J:175213 )

digestive/alimentary system

right-sided stomach ( J:175213 )

growth/size/body

heterotaxia ( J:175213 )

right-sided stomach ( J:175213 )

left-sided isomerism ( J:175213 )

right pulmonary isomerism ( J:175213 )

hematopoietic system

spleen hypoplasia ( J:175213 )

accessory spleen ( J:175213 )

immune system

spleen hypoplasia ( J:175213 )

accessory spleen ( J:175213 )

respiratory system

right pulmonary isomerism ( J:175213 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213