Phenotypes Associated with This Genotype

Genotype
MGI:5562546

tg2

• Allelic Composition: Tg(SERPINA1*E342K)#Slcw/0
• Genetic Background: involves: C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver inflammation ( J:149132 )

• clusters of leukocytes are associated with foci of necrosis and leukocytic infiltrates are seen occasionally in portal tracts and in surrounding terminal hepatic veins

abnormal hepatocyte morphology ( J:149132 , J:208016 )

• hepatocytes exhibit numerous cytoplasmic globular inclusions (J:149132)

hepatic necrosis ( J:149132 )

• multiple small foci of necrosis are present in the liver and these areas show fragmentation of hepatocytes and globules

immune system

liver inflammation ( J:149132 )

• clusters of leukocytes are associated with foci of necrosis and leukocytic infiltrates are seen occasionally in portal tracts and in surrounding terminal hepatic veins

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:208016 )

• young mice show mild elevations in liver enzymes such as alanine transaminase and aspartate aminotransferase