Phenotypes Associated with This Genotype

Genotype
MGI:5562646

• Allelic Composition: Slit3^tm1.1Dor/Slit3^tm1.1Dor
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:208012 )

• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions

• diaphragmatic tendon vessels show diverse diameters and sprout discontinuity and vascular plexus density are reduced

• vascular density and sprouting in diaphragmatic muscle is reduced

muscle

abnormal diaphragm morphology ( J:208012 )

• vascular density and sprouting in diaphragmatic muscle is reduced

• microvessels in the diaphragm are dilated and disorganized some vessels terminate with large, distended heads with fewer extending filopodia rather than sprouting and communicating with neighboring vessels

• tip endothelial cells are reduced by 89% in diaphragms

abnormal diaphragm central tendon morphology ( J:208012 )

• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions

diaphragmatic hernia ( J:208012 )

• 86% of mice exhibit central tendon congenital diaphragmatic hernia

skeleton

abnormal diaphragm central tendon morphology ( J:208012 )

• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital diaphragmatic hernia		DOID:3827	OMIM:142340 OMIM:222400 OMIM:610187	J:208012