Phenotypes Associated with This Genotype

Genotype
MGI:5562921

• Allelic Composition: Tg(SERPINA1*E342K)#Slcw/Tg(SERPINA1*E342K)#Slcw
• Genetic Background: involves: C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:208016 )

• mice show elevations in liver enzymes such as alanine transaminase and aspartate aminotransferase

liver/biliary system

liver fibrosis ( J:208016 )

• mice show liver fibrosis around 4 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha 1-antitrypsin deficiency		DOID:13372	OMIM:613490	J:208016