mortality/aging
• feeding with soft chow does not improve survival
• die within 30 days of age
|
growth/size/body
• lack tooth eruption
|
craniofacial
• lack tooth eruption
|
nervous system
• extensive neurodegeneration in the hippocampal regions and cerebellar cortex
|
skeleton
• lack tooth eruption
|
• fibrotic bone marrow
|
• mice are severely osteopetrotic
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
autosomal dominant osteopetrosis 2 | DOID:0110938 |
OMIM:166600 |
J:203761 |