Phenotypes Associated with This Genotype

Genotype
MGI:5563141

• Allelic Composition: Clcn7^tm1.1Mjec/Clcn7⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:203761 )

skeleton

increased bone mineral density ( J:203761 )

• Background Sensitivity: 4% increase in whole body areal bone mineral density on the DBA/2J background compared to 8% increase on a 129 background and 3.8% on a BALB/cJ background

abnormal trabecular bone morphology ( J:203761 )

• trabecular separation is lower

increased trabecular bone volume ( J:203761 )

increased bone trabecula number ( J:203761 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant osteopetrosis 2		DOID:0110938	OMIM:166600	J:203761