Phenotypes Associated with This Genotype

Genotype
MGI:5563665

• Allelic Composition: Tg(KRT14-Il18)#Knak/0
• Genetic Background: C57BL/6-Tg(KRT14-Il18)#Knak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

dermatitis ( J:78602 )

• mice develop skin diseases at about 6 months after birth, showing inflammatory skin lesions with high concentration of IgE

• dermis is severely infiltrated with lymphocytes and polymorphonuclear cells, such as neutrophils

• mast cell number is increased in the dermal infiltrates

acanthosis ( J:78602 )

• epidermis is acanthotic

skin lesions ( J:78602 )

• late onset of skin lesions, which start as focal skin alterations around their eyes but gradually extend to the face, head and trunk

• presence of marked lichenification without scarring

behavior/neurological

excessive scratching ( J:78602 )

• mice frequently scratch their skin, particularly the skin lesion

hematopoietic system

increased neutrophil cell number ( J:78602 )

• proportion of neutrophils, as determined by Gr-1+ Mac-1+ cells, is elevated in the spleen

decreased T cell number ( J:78602 )

• splenic lymphocytes show a lower proportion of T cells compared to wild-type mice

increased IgE level ( J:78602 )

increased IgG1 level ( J:78602 )

abnormal T cell physiology ( J:78602 )

• isolated CD4+ T cells produce more IL-4, but less IFN-gamma, in response to immobilized anti-CD3, compared to wild-type mice

homeostasis/metabolism

increased circulating histamine level ( J:78602 )

• elevation of plasma histamine levels

increased circulating interleukin-18 level ( J:78602 )

immune system

increased neutrophil cell number ( J:78602 )

• proportion of neutrophils, as determined by Gr-1+ Mac-1+ cells, is elevated in the spleen

decreased T cell number ( J:78602 )

• splenic lymphocytes show a lower proportion of T cells compared to wild-type mice

increased IgE level ( J:78602 )

increased IgG1 level ( J:78602 )

abnormal T cell physiology ( J:78602 )

• isolated CD4+ T cells produce more IL-4, but less IFN-gamma, in response to immobilized anti-CD3, compared to wild-type mice

increased circulating interleukin-18 level ( J:78602 )

dermatitis ( J:78602 )

• mice develop skin diseases at about 6 months after birth, showing inflammatory skin lesions with high concentration of IgE

• dermis is severely infiltrated with lymphocytes and polymorphonuclear cells, such as neutrophils

• mast cell number is increased in the dermal infiltrates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:78602