integument
• 90% of mice show mild-to-moderate spongiosis from 6 weeks onward
|
• 12 week old mutants exhibit a 4-fold increase in transepidermal water loss indicating that skin barrier function is disturbed; an increase is already seen at 3 weeks
• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks diminishes loss of barrier function
|
• eosinophil, mast cell, CD4+ T cell, and macrophage infiltration into the skin by 6 weeks of age
• treatment with a corticosteroid cream for 3 weeks diminishes the number of granulocytes, macrophages and CD4+ t cells, but had no effect on mast cells
|
dermatitis
(
J:135501
)
• mice develop signs of atopic dermatitis, comprising scaling, lichenification, papules and mild-to-severe excoriations from an age of 6 weeks
• dermatitis is evident in the upper dorsal skin and with age, the head and eyelids become affected
• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks decreases severity of dermatitis
|
• epidermal hyperplasia
• treatment with a corticosteroid cream for 3 weeks inhibits epidermal hyperplasia but results in thinning of the epidermis
|
scaly skin
(
J:135501
)
• frequency of scratching and duration at 9 weeks of age is increased and increases further with age
|
immune system
• mast cells show degranulation
|
• serum IgE levels are increased at 12 weeks of age, but not at 8 weeks of age
• from 12 weeks of age, mast cells in the dermis become IgE-positive
|
• eosinophil, mast cell, CD4+ T cell, and macrophage infiltration into the skin by 6 weeks of age
• treatment with a corticosteroid cream for 3 weeks diminishes the number of granulocytes, macrophages and CD4+ t cells, but had no effect on mast cells
|
dermatitis
(
J:135501
)
• mice develop signs of atopic dermatitis, comprising scaling, lichenification, papules and mild-to-severe excoriations from an age of 6 weeks
• dermatitis is evident in the upper dorsal skin and with age, the head and eyelids become affected
• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks decreases severity of dermatitis
|
behavior/neurological
• frequency of scratching and duration at 9 weeks of age is increased and increases further with age
|
hematopoietic system
• mast cells show degranulation
|
• serum IgE levels are increased at 12 weeks of age, but not at 8 weeks of age
• from 12 weeks of age, mast cells in the dermis become IgE-positive
|
homeostasis/metabolism
• 90% of mice show mild-to-moderate spongiosis from 6 weeks onward
|
• 12 week old mutants exhibit a 4-fold increase in transepidermal water loss indicating that skin barrier function is disturbed; an increase is already seen at 3 weeks
• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks diminishes loss of barrier function
|
cellular
• mast cells show degranulation
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
atopic dermatitis | DOID:3310 |
OMIM:603165 OMIM:PS603165 |
J:135501 |