Phenotypes Associated with This Genotype

Genotype
MGI:5564982

• Allelic Composition: Tg(KRT14-Il4)#Lsch/0
• Genetic Background: involves: BALB/cBy * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

epidermal spongiosis ( J:126285 )

• mild spongiosis in early and chronic inflammatory lesions

skin inflammation ( J:126285 )

• early inflammatory lesions show a dermal and epidermal infiltration of mononuclear cells and actively degranulating mast cells in the dermis

• chronic inflammatory lesions show prominent dermal mononuclear cell infiltration, dermal eosinophil infiltration, and mast cell degranulation

• prominent epidermal and dermal infiltrate of CD3+ T cells in early inflammatory lesions

• in crusting skin lesions, epidermis is absent and is replaced by serous materials and numerous neutrophils

dermatitis ( J:126285 )

• 17 of 40 mice develop dermatitis within a 12 month period

• skin lesions are characterized by chronic dermatitis, mononuclear cell infiltration, and mast cell degranulation

hyperkeratosis ( J:126285 )

• in chronic inflammatory lesions

parakeratosis ( J:126285 )

• focal areas of parakeratosis in chronic inflammatory lesions

acanthosis ( J:126285 )

• in both early and chronic inflammatory lesions

dry skin ( J:126285 )

• xerosis is seen at 4 months of age

spontaneous skin ulceration ( J:126285 )

• inflammatory skin lesions surface around 4 months of age

• skin lesions initially occur at the ears and subsequently extend to the neck, mouth, around the eyes, tail and legs

• 100% of mice show ear lesions, 65% show neck lesions, 53% show lesions around the eyes, 29% show lesions on the face, 12% show tail lesions, 12% show leg lesions and 6% show lesions on the torso

increased pruritus ( J:126285 )

• skin lesions appear to be pruritic, with mice showing constant face rubbing and scratching

behavior/neurological

excessive scratching ( J:126285 )

• skin lesions appear to be pruritic, with mice showing constant face rubbing and scratching

immune system

increased mast cell degranulation ( J:126285 )

• mast cell degranulation in skin lesions

increased IgE level ( J:126285 )

increased IgG1 level ( J:126285 )

decreased IgG2a level ( J:126285 )

• total serum IgG2a levels are slightly reduced

blepharitis ( J:126285 )

conjunctivitis ( J:126285 )

skin inflammation ( J:126285 )

• early inflammatory lesions show a dermal and epidermal infiltration of mononuclear cells and actively degranulating mast cells in the dermis

• chronic inflammatory lesions show prominent dermal mononuclear cell infiltration, dermal eosinophil infiltration, and mast cell degranulation

• prominent epidermal and dermal infiltrate of CD3+ T cells in early inflammatory lesions

• in crusting skin lesions, epidermis is absent and is replaced by serous materials and numerous neutrophils

dermatitis ( J:126285 )

• 17 of 40 mice develop dermatitis within a 12 month period

• skin lesions are characterized by chronic dermatitis, mononuclear cell infiltration, and mast cell degranulation

increased susceptibility to bacterial infection ( J:126285 )

• infection of the skin lesions occurs following self-inflicted excoriation which slowly destroys the external ears

• 47% of mice develop bacterial pyoderma at the external ear

• inflammatory skin lesions precede the onset of pyoderma

hematopoietic system

increased mast cell degranulation ( J:126285 )

• mast cell degranulation in skin lesions

increased IgE level ( J:126285 )

increased IgG1 level ( J:126285 )

decreased IgG2a level ( J:126285 )

• total serum IgG2a levels are slightly reduced

homeostasis/metabolism

epidermal spongiosis ( J:126285 )

• mild spongiosis in early and chronic inflammatory lesions

vision/eye

blepharitis ( J:126285 )

conjunctivitis ( J:126285 )

abnormal conjunctiva morphology ( J:126285 )

• eyelid dermatitis, blepharitis, and conjunctivitis result in corneal and conjunctival scarring

cornea scarring ( J:126285 )

• eyelid dermatitis, blepharitis, and conjunctivitis result in corneal and conjunctival scarring

abnormal eyelid morphology ( J:126285 )

• eyelid dermatitis

cellular

increased mast cell degranulation ( J:126285 )

• mast cell degranulation in skin lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:126285