Phenotypes Associated with This Genotype

Genotype
MGI:5565220

• Allelic Composition: Tg(Ins2-HBEGF)5Rin/?
• Genetic Background: C57BL/6-Tg(Ins2-HBEGF)5Rin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hyperglycemia ( J:204420 )

• blood glucose is elevated after administration of diphtheria toxin (DT)

• the hyperglycemia of DT treated mice is decreased by insulin injection

decreased circulating insulin level ( J:204420 )

• plasma insulin levels are decreased 5 days after administration of DT

• following glucose challenge, insulin levels are not increased in DT treated mice

increased urine glucose level ( J:204420 )

• following DT administration

ketoaciduria ( J:204420 )

• following DT administration

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:204420 )

• pancreatic islets are irregularly arranged, with alpha and beta cells randomly mixed rather than 80% of beta cells surrounded by 20% of other cells, after administration of DT

decreased pancreatic beta cell number ( J:204420 )

• administration of DT results in a drastic decrease in the number of pancreatic beta cells

renal/urinary system

increased urine glucose level ( J:204420 )

• following DT administration

ketoaciduria ( J:204420 )

• following DT administration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:204420