Phenotypes Associated with This Genotype

Genotype
MGI:5565224

• Allelic Composition: Prkdc^scid/Prkdc^scid; Tg(INS-HBEGF*L148S*P149T)70Rin/0
• Genetic Background: C.BKa-Prkdc^scid Tg(INS-HBEGF*L148S*P149T)70Rin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hyperglycemia ( J:204420 )

• blood glucose is elevated 2 days after administration of diphtheria toxin (DT)

• hyperglycemia is maintained for 65 days after DT administration

• the hyperglycemia of DT treated mice is decreased by insulin injection

• transplantation of wild-type pancreatic islets beneath the renal capsule of DT treated mice brings blood glucose levels to normal

decreased circulating insulin level ( J:204420 )

• plasma insulin levels are decreased 5 days after administration of DT

• following glucose challenge, insulin levels are not increased in DT treated mice

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:204420 )

• pancreatic islets are irregularly arranged, with alpha and beta cells randomly mixed rather than 80% of beta cells surrounded by 20% of other cells, after administration of DT

decreased pancreatic beta cell number ( J:204420 )

• administration of DT results in a drastic decrease in the number of pancreatic beta cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:204420