Phenotypes Associated with This Genotype

Genotype
MGI:5565367

• Allelic Composition: Met^tm4Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:151890 )

♀ • both nulliparous and multiparous females develop mammary tumors with high penetrance

♀ • mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation

♀ • mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia

♀ • solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells

♀ • significant squamous metaplasia is seen in 65% of mammary tumors

♀ • tumors are often estrogen receptor-positive and progesterone receptor-negative

increased mammary adenocarcinoma incidence ( J:151890 )

♀ • mammary adenocarcinoma with squamous metaplasia or/and with solid patterns

♀ • mammary adenocarcinomas show high levels of Met amplification and trisomy

increased squamous cell carcinoma incidence ( J:151890 )

♀ • mammary squamous cell carcinoma

increased sarcoma incidence ( J:151890 )

♀ • undifferentiated mammary sarcomas

increased hemangiosarcoma incidence ( J:151890 )

♀ • mammary hamangiosarcoma

increased myoepithelioma incidence ( J:151890 )

♀ • mammary myoepithelioma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:151890 )

♀ • both nulliparous and multiparous females develop mammary tumors with high penetrance

♀ • mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation

♀ • mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia

♀ • solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells

♀ • significant squamous metaplasia is seen in 65% of mammary tumors

♀ • tumors are often estrogen receptor-positive and progesterone receptor-negative

increased mammary adenocarcinoma incidence ( J:151890 )

♀ • mammary adenocarcinoma with squamous metaplasia or/and with solid patterns

♀ • mammary adenocarcinomas show high levels of Met amplification and trisomy

integument

increased mammary gland tumor incidence ( J:151890 )

♀ • both nulliparous and multiparous females develop mammary tumors with high penetrance

♀ • mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation

♀ • mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia

♀ • solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells

♀ • significant squamous metaplasia is seen in 65% of mammary tumors

♀ • tumors are often estrogen receptor-positive and progesterone receptor-negative

increased mammary adenocarcinoma incidence ( J:151890 )

♀ • mammary adenocarcinoma with squamous metaplasia or/and with solid patterns

♀ • mammary adenocarcinomas show high levels of Met amplification and trisomy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:151890