Phenotypes Associated with This Genotype

Genotype
MGI:5565512

• Allelic Composition: Flt3^tm1.1Dosm/Flt3⁺
• Genetic Background: B6.129(C)-Flt3^tm1.1Dosm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:205200 )

• median survival is 430 days

hematopoietic system

abnormal definitive hematopoiesis ( J:205200 )

• impaired ability to engraft in a competitive repopulation assay

arrested B cell differentiation ( J:205200 )

• severe block in B cell development with few cells progressing past the early pro-B cell stage

abnormal bone marrow cell number ( J:205200 )

• normal architecture is largely replaced by myeloid progenitors in mice at 3 and 12 months of age

decreased bone marrow cell number ( J:205200 )

• decrease in the fraction of functional c-Kit+ Sca-1+ Lin-(KSL)-signaling lymphocyte activation molecule (KSL-SLAM) cells

increased bone marrow cell number ( J:205200 )

• increase in the fractions of c-Kit+ Sca-1+ Lin- (KSL) and multipotent progenitor (Lin-c-Kit+Sca-1+CD135+CD34+) cells in the bone marrow

abnormal spleen morphology ( J:205200 )

• architecture disruption and cellular expansion at 3 and 12 months of age

enlarged spleen ( J:205200 )

• detected at 12 weeks of age

increased spleen white pulp amount ( J:205200 )

abnormal bone marrow cell physiology ( J:205200 )

• treatment with either Lestaurtinib or Sorafenib decreases bone marrow cell proliferation

skeleton

abnormal bone marrow morphology ( J:205200 )

• architecture disruption and cellular expansion at 3 and 12 months of age

• normal architecture is largely replaced by myeloid progenitors in mice at 3 and 12 months of age

immune system

arrested B cell differentiation ( J:205200 )

• severe block in B cell development with few cells progressing past the early pro-B cell stage

abnormal spleen morphology ( J:205200 )

• architecture disruption and cellular expansion at 3 and 12 months of age

enlarged spleen ( J:205200 )

• detected at 12 weeks of age

increased spleen white pulp amount ( J:205200 )

growth/size/body

enlarged spleen ( J:205200 )

• detected at 12 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:205200