Phenotypes Associated with This Genotype

Genotype
MGI:5565691

• Allelic Composition: Tg(UBC-GFP/HTT*84Q)22Shya/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:209055 )

• survival rate at 13 months is 33%

premature death ( J:209055 )

• some mice start to die at 5 months of age and survival rate at 13 months is about 33%

behavior/neurological

limb grasping ( J:209055 )

• clasping behavior is seen after 8.5 months of age

impaired coordination ( J:209055 )

• mice are unbalanced on the rotarod while running and exhibit a higher tendency to fall off during three consecutive days at the end stage

decreased grip strength ( J:209055 )

• mice show weaker grasping strength after 8.5 months of age that becomes progressively worse with age

abnormal gait ( J:209055 )

• mice show disordered and shorter stride length, dragging, and uneven step patterns and unbalanced gaits when walking through a tunnel at the end stage

short stride length ( J:209055 )

• in aged mice

nervous system

neuronal intranuclear inclusions ( J:209055 )

• nuclear aggregates, intranuclear aggregates, and neuropil aggregates and inclusion bodies are seen in the cortex and striatum regions at 12 months of age, but not at 2 months

• more nuclear aggregates and inclusion bodies are seen in the striatum while neuropil aggregates are predominately seen in the cortex region

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:209055