Analysis Tools
mortality/aging
 |
• most mice die by 15 months of age
|
neoplasm
|
|
• a few mice develop unidentified tumors in the scrotal region, not obviously associated with the testes; these tumors are cystic and epithelial in origin
|
|
|
• all prostate lobes exhibit neoplasia with hyperplasia, multiple foci of squamous metaplasia and keratinization, and a prominent stromal reaction, including edema, inflammatory reaction and stromal hyperplasia by 7 months of age indicating adenocarcinoma
• the anterior prostate shows the most severe phenotype, followed by the dorsal-lateral and then ventral prostate
• small foci of tumor invasion into the stroma is seen but this is not common
• mice castrated at 6 weeks show regions of hyperplasia, and squamous metaplasia at 32 weeks later, but not carcinoma, indicating inhibition of tumor formation
• mice castrated after tumors still exhibit carcinoma 2 months postcastration
|
|
|
• mice develop prostatic epithelial hyperplasia and prostatic intraepithelial neoplasia (PIN) as early as 4.5 to 7 weeks of age
|
endocrine/exocrine glands
|
|
• mice develop prostatic epithelial hyperplasia as early as 4.5 to 7 weeks of age
|
|
|
• all prostate lobes exhibit neoplasia with hyperplasia, multiple foci of squamous metaplasia and keratinization, and a prominent stromal reaction, including edema, inflammatory reaction and stromal hyperplasia by 7 months of age indicating adenocarcinoma
• the anterior prostate shows the most severe phenotype, followed by the dorsal-lateral and then ventral prostate
• small foci of tumor invasion into the stroma is seen but this is not common
• mice castrated at 6 weeks show regions of hyperplasia, and squamous metaplasia at 32 weeks later, but not carcinoma, indicating inhibition of tumor formation
• mice castrated after tumors still exhibit carcinoma 2 months postcastration
|
|
|
• mice develop prostatic epithelial hyperplasia and prostatic intraepithelial neoplasia (PIN) as early as 4.5 to 7 weeks of age
|
reproductive system
|
|
• mice develop prostatic epithelial hyperplasia as early as 4.5 to 7 weeks of age
|
|
|
• all prostate lobes exhibit neoplasia with hyperplasia, multiple foci of squamous metaplasia and keratinization, and a prominent stromal reaction, including edema, inflammatory reaction and stromal hyperplasia by 7 months of age indicating adenocarcinoma
• the anterior prostate shows the most severe phenotype, followed by the dorsal-lateral and then ventral prostate
• small foci of tumor invasion into the stroma is seen but this is not common
• mice castrated at 6 weeks show regions of hyperplasia, and squamous metaplasia at 32 weeks later, but not carcinoma, indicating inhibition of tumor formation
• mice castrated after tumors still exhibit carcinoma 2 months postcastration
|
|
|
• mice develop prostatic epithelial hyperplasia and prostatic intraepithelial neoplasia (PIN) as early as 4.5 to 7 weeks of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| prostate cancer | DOID:10283 |
OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 |
J:120308 | |
