Phenotypes Associated with This Genotype

Genotype
MGI:5566661

• Allelic Composition: Tg(Pbsn-Tag)12T10Rjm/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:48623 )

♂ • slow growing prostate tumors

increased prostate gland adenocarcinoma incidence ( J:48623 , J:68483 )

♂ (J:48623)

♂ • high-grade PIN progresses to invasive carcinoma (J:68483)

♂ • microinvasive carcinoma is seen in mice older than 4 months of age and invasive carcinoma is seen in mice older than 6 months of age (J:68483)

♂ • invasive carcinoma or undifferentiated carcinoma are present in 40% of 6-7 month old mice, 67% of 8-10 month old mice, and 100% of 11-12 month old mice (J:68483)

♂ • small but definitive foci of invasive carcinoma are composed of nests with definitive glandular differentiation indicating adenocarcinoma, nests with features of neuroendocrine differentiation, including scant cytoplasm, nuclear molding, and rosette formation, and small nests of malignant epithelial cells with varying amounts of cytoplasm and no glandular or neuroendocrine differentiation (J:68483)

♂ • 8% of small invasive foci show features of both glandular and neuroendocrine differentiation (J:68483)

♂ • undifferentiated carcinomas are not seen in mice younger than 7 months of age, are present in 20% of 8 month old mice and 29% of mice older than 9 months of age (J:68483)

♂ • undifferentiated carcinomas show features typical neuroendocrine carcinomas (J:68483)

increased prostate intraepithelial neoplasia incidence ( J:68483 )

♂ • most prostate lobes of 2-5 month old mice exhibit epithelial proliferation with mild nuclear atypia indicative of low-grade prostatic intraepithelial neoplasia (PIN)

♂ • epithelial proliferation, nuclear stratification, and cytological atypia progresses quickly such that high-grade prostatic intraepithelial neoplasia is seen uniformly throughout preexisting glands and ducts by 6 months of age

increased metastatic potential ( J:68483 )

♂ • metastatic carcinoma occurs with increasing frequency with age; 40% of mice 6-8 months of age and 88% of mice 9-12 months of age exhibit metastases most commonly into regional lymph nodes, liver, and lung

♂ • metastatic carcinoma is composed of large sheets of cells with neuroendocrine differentiation, however, definitive adenocarcinoma morphology is not seen in metastatic foci

♂ • 33% of mice with microinvasive carcinoma, 69% of mice with invasive carcinoma, and 100% of mice with undifferentiated carcinoma have metastases

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:48623 )

♂ • slow growing prostate tumors

increased prostate gland adenocarcinoma incidence ( J:48623 , J:68483 )

♂ (J:48623)

♂ • high-grade PIN progresses to invasive carcinoma (J:68483)

♂ • microinvasive carcinoma is seen in mice older than 4 months of age and invasive carcinoma is seen in mice older than 6 months of age (J:68483)

♂ • invasive carcinoma or undifferentiated carcinoma are present in 40% of 6-7 month old mice, 67% of 8-10 month old mice, and 100% of 11-12 month old mice (J:68483)

♂ • small but definitive foci of invasive carcinoma are composed of nests with definitive glandular differentiation indicating adenocarcinoma, nests with features of neuroendocrine differentiation, including scant cytoplasm, nuclear molding, and rosette formation, and small nests of malignant epithelial cells with varying amounts of cytoplasm and no glandular or neuroendocrine differentiation (J:68483)

♂ • 8% of small invasive foci show features of both glandular and neuroendocrine differentiation (J:68483)

♂ • undifferentiated carcinomas are not seen in mice younger than 7 months of age, are present in 20% of 8 month old mice and 29% of mice older than 9 months of age (J:68483)

♂ • undifferentiated carcinomas show features typical neuroendocrine carcinomas (J:68483)

increased prostate intraepithelial neoplasia incidence ( J:68483 )

♂ • most prostate lobes of 2-5 month old mice exhibit epithelial proliferation with mild nuclear atypia indicative of low-grade prostatic intraepithelial neoplasia (PIN)

♂ • epithelial proliferation, nuclear stratification, and cytological atypia progresses quickly such that high-grade prostatic intraepithelial neoplasia is seen uniformly throughout preexisting glands and ducts by 6 months of age

reproductive system

increased prostate gland tumor incidence ( J:48623 )

♂ • slow growing prostate tumors

increased prostate gland adenocarcinoma incidence ( J:48623 , J:68483 )

♂ (J:48623)

♂ • high-grade PIN progresses to invasive carcinoma (J:68483)

♂ • microinvasive carcinoma is seen in mice older than 4 months of age and invasive carcinoma is seen in mice older than 6 months of age (J:68483)

♂ • invasive carcinoma or undifferentiated carcinoma are present in 40% of 6-7 month old mice, 67% of 8-10 month old mice, and 100% of 11-12 month old mice (J:68483)

♂ • small but definitive foci of invasive carcinoma are composed of nests with definitive glandular differentiation indicating adenocarcinoma, nests with features of neuroendocrine differentiation, including scant cytoplasm, nuclear molding, and rosette formation, and small nests of malignant epithelial cells with varying amounts of cytoplasm and no glandular or neuroendocrine differentiation (J:68483)

♂ • 8% of small invasive foci show features of both glandular and neuroendocrine differentiation (J:68483)

♂ • undifferentiated carcinomas are not seen in mice younger than 7 months of age, are present in 20% of 8 month old mice and 29% of mice older than 9 months of age (J:68483)

♂ • undifferentiated carcinomas show features typical neuroendocrine carcinomas (J:68483)

increased prostate intraepithelial neoplasia incidence ( J:68483 )

♂ • most prostate lobes of 2-5 month old mice exhibit epithelial proliferation with mild nuclear atypia indicative of low-grade prostatic intraepithelial neoplasia (PIN)

♂ • epithelial proliferation, nuclear stratification, and cytological atypia progresses quickly such that high-grade prostatic intraepithelial neoplasia is seen uniformly throughout preexisting glands and ducts by 6 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate adenocarcinoma		DOID:2526		J:68483