Phenotypes Associated with This Genotype

Genotype
MGI:5566682

• Allelic Composition: Tg(YAC128)#Hay/0
• Genetic Background: FVB/N-Tg(YAC128)#Hay

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:98736 )

• mutants take longer to reach the platform in a swimming test starting at 8 months of age, primarily as a result of choosing the incorrect direction to swim at the outset

• mutants show a deficit in changing strategy that is apparent in the path and time it takes to reach the platform in the reversal of the T-maze test, which training reduces

• 2 month old presymptomatic mutants exhibit difficulty in shifting strategy when the location of the platform is switched to the opposite arm of the maze, taking longer to reach to the platform during the reversal phase of the swimming T-maze test

abnormal motor learning ( J:98736 )

• motor learning on the rotarod worsens with time, leading to complete inability to learn to the task at 12 months of age

• mutants that are trained on the rotarod at an earlier age are able to appropriately perform the task at 12 months of age, indicating that mice that are first trained on the task at an older age of 12 months and are unable to stay on the rotarod have a learning deficit in addition to impaired motor coordination

• 8 month old mutants exhibit a slower swimming speed and take longer to find the platform in a simple swimming test

abnormal habituation ( J:98736 )

• mutants at 12 months of age show decreased habituation to acoustic startle, indicating a deficit in learning and memory

abnormal habituation to a new environment ( J:98736 )

• 8 month old, but not 2 month old, mutants exhibit impaired memory in the open-field habituation test, showing decreased intrasession and intersession habituation

impaired spatial learning ( J:98736 )

• 8.5 month old mutants take longer to reach the escape platform in the swimming T-maze, have several errant trials that are much slower than average, and show increased pausing and decreased swimming speed

• in the reversal phase of the swimming T-maze test, aged mutants show more arm entries to reach the platform and take twice as long as wild-type mice to reach the platform in the first trial

abnormal startle reflex ( J:98736 )

• mutants at 12 months of age show decreased habituation to acoustic startle, indicating a deficit in learning and memory

impaired coordination ( J:98736 )

• mutants exhibit a deficit in motor coordination on the fixed and the accelerating rotarod that develops at 4 months of age and progressively worsens over time; this deficit is preceded by mild impairments in motor learning that occur at 2 months of age

impaired swimming ( J:98736 )

• 8 month old mutants exhibit a slower swimming speed in a simple swimming test

nervous system

reduced sensorimotor gating ( J:98736 )

• mutants at 12, but not 9, months of age show less prepulse inhibition (PPI), indicating a deficit in sensorimotor gating

decreased prepulse inhibition ( J:98736 )

• mutants at 12, but not 9, months of age show less prepulse inhibition (PPI), indicating a deficit in sensorimotor gating

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:98736