Phenotypes Associated with This Genotype

Genotype
MGI:5566851

• Allelic Composition: Rho^tm1.1Eye/Rho⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal retina photoreceptor morphology ( J:205477 )

• progressive loss of photoreceptor neurons

short photoreceptor outer segment ( J:205477 )

• diminished outer segment length at P21

vision/eye

abnormal retina morphology ( J:205477 )

• mice show an age-related increase in overall autofluorescence and develop a progressively increasing number of diffuse, subretinal, hyperfluorescent dots

abnormal retina photoreceptor morphology ( J:205477 )

• progressive loss of photoreceptor neurons

short photoreceptor outer segment ( J:205477 )

• diminished outer segment length at P21

thin retina outer nuclear layer ( J:205477 )

• slightly reduced outer nuclear layer thickness at P21

decreased a-wave amplitude ( J:205477 )

• scotopic a-wave amplitudes are reduced at high-stimulus intensities at P21, indicating desensitization of photoreceptors

decreased b-wave amplitude ( J:205477 )

• b-wave amplitude is lower, especially at lower intensities, at P100, but normal at P21

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:205477