Phenotypes Associated with This Genotype

Genotype
MGI:5567079

cn1

• Allelic Composition: Nlgn2^tm1.1Sud/Nlgn2^tm1.1Sud
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synapse morphology ( J:229887 )

• GAD65-positive synapse density is decreased 6-7 weeks following injection of adeno-associated virus (AAV) expressing Cre recombinase

• 15% decrease in inhibitory synapse numbers in medial prefrontal cortex 6-7 weeks following AAV-cre

• no major change in passive or active neuron membrane properties are detected

abnormal CNS synaptic transmission ( J:229887 )

• 45% decrease in synaptic transmission in medial prefrontal cortex following AAV-cre

abnormal inhibitory postsynaptic currents ( J:229887 )

• decreased IPSC amplitudes 6-7 weeks following AAV-cre, but no decrease in EPSC amplitudes

• decrease is not detected 2-3 weeks following AAV-cre injection

• E/I ratio is increased 6-7 weeks following AAV-cre injection

abnormal miniature inhibitory postsynaptic currents ( J:229887 )

• amplitude and frequency of mIPSC is decreased 6-7 weeks following AAV-cre

• no changes in mEPSC amplitude or frequency are detected

decreased miniature inhibitory postsynaptic current amplitude ( J:229887 )

• at 6-7 weeks following AAV-cre

decreased miniature inhibitory postsynaptic current frequency ( J:229887 )

• at 6-7 weeks following AAV-cre

behavior/neurological

behavior/neurological phenotype ( J:229887 )

N • no alteration in rotarod performance, open field tests and Y-maze tests as compared to controls

impaired contextual conditioning behavior ( J:229887 )

• decrease in contextual fear conditioning beginning 2-3 weeks following AAV-cre

impaired cued conditioning behavior ( J:229887 )

• decrease in cued fear conditioning beginning 2-3 weeks following AAV-cre

decreased anxiety-related response ( J:229887 )

• mice spend more time in open arms of elevated plus maze beginning 2-3 weeks following AAV-cre

social withdrawal ( J:229887 )

• decrease in social interactions observed 6-7 weeks following AAV-cre