Phenotypes Associated with This Genotype

Genotype
MGI:5568994

• Allelic Composition: Mecp2^tm1.1Jtc/Y
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

lethargy ( J:209637 )

♂ • mice appear lethargic by postnatal day 50

impaired long-term object recognition memory ( J:209637 )

♂ • object memory is intact at 1 hour, but impaired 24 hours after object training

increased anxiety-related response ( J:209637 )

♂ • increased time spent in open arms as compared to wild type on postnatal day 25

♂ • increased number of open arm entries as compared to wild type on on postnatal day 25

♂ • increased travel distance in zero maze as compared to wild type control on postnatal day 25

increased fear-related response ( J:209637 )

♂ • males freeze for a larger percentage of time as compared to wild type on postnatal day 35, however, males freeze for smaller percentage of time on both context and cued memory tasks

impaired coordination ( J:209637 )

♂ • reduced latency to fall from rotarod as compared to wild type on postnatal day 29

decreased grip strength ( J:209637 )

♂ • decreased forelimb grip strength as compared to wild type on postnatal day 25

decreased locomotor activity ( J:209637 )

♂ • reduced ambulatory movements (two consecutive beam breaks) as compared to wild type first observed at postnatal day 24

♂ • reduced fine motor movements (repeated breaking of same beam) as compared to wild type observed at postnatal day 43

growth/size/body

decreased body weight ( J:209637 )

♂ • reduced body weight as compared to wild type on postnatal day 25

integument

ruffled hair ( J:209637 )

♂ • ruffled fur observed by postnatal day 50

respiratory system

abnormal respiration ( J:209637 )

♂ • respiratory abnormalities observed by postnatal day 50

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:209637