Phenotypes Associated with This Genotype

Genotype
MGI:5569019

• Allelic Composition: Tg(Ins1-Cd80)378Psoh/0; Tg(Ins2-GP)#Psoh/0; Tg(TcrLCMV)327Sdz/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:209714 )

• hyperglycemia is followed by ketosis, wasting, and death

endocrine/exocrine glands

absent pancreatic beta cells ( J:209714 )

• complete beta-cell destruction

insulitis ( J:209714 )

• ongoing insulitis is seen at 10 weeks of age, with a diminished, but still present, mass of beta cells

• 4 week old mice show a mixture of a few cD8+ and CD4+ T lymphocytes and an increase in the number of macrophages surrounding pancreatic islets, while 9 week old mice show severe insulitis and periinsulitis with CD8+ and CD4+ T lymphocytes, macrophages and B lymphocytes infiltrating the islets

periinsulitis ( J:209714 )

• 9 week old mice show severe periinsulitis

growth/size/body

cachexia ( J:209714 )

• hyperglycemia is wasting

homeostasis/metabolism

hyperglycemia ( J:209714 )

• mice spontaneously become diabetic with a median age of hyperglycemia onset of 9-10 weeks of age

ketosis ( J:209714 )

• hyperglycemia is followed by ketosis

immune system

insulitis ( J:209714 )

• ongoing insulitis is seen at 10 weeks of age, with a diminished, but still present, mass of beta cells

• 4 week old mice show a mixture of a few cD8+ and CD4+ T lymphocytes and an increase in the number of macrophages surrounding pancreatic islets, while 9 week old mice show severe insulitis and periinsulitis with CD8+ and CD4+ T lymphocytes, macrophages and B lymphocytes infiltrating the islets

periinsulitis ( J:209714 )

• 9 week old mice show severe periinsulitis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:209714