Phenotypes Associated with This Genotype

Genotype
MGI:5569537

• Allelic Composition: Tg(CMV-HTT*89Q)ATag/Tg(CMV-HTT*89Q)ATag
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grooming behavior ( J:50173 )

• begins at 16 weeks of age

hyperactivity ( J:50173 )

• begins at 16 weeks of age

unidirectional circling ( J:50173 )

• begins at 16 weeks of age

increased stereotypic behavior ( J:50173 )

• 15 of 40 mice show stereotypy beginning at 16 weeks of age, consisting of generalized hyperactive behavior, including unidirectional rotations, backflips, and excessive grooming

nervous system

neuron degeneration ( J:50173 )

• approximately 20% fewer small and medium neurons in the striata

• neuronal loss is also seen in the hippocampus, thalamus, cerebral cortex, and cerebellum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:50173