Phenotypes Associated with This Genotype

Genotype
MGI:5569928

• Allelic Composition: Nkx3-1^tm1Mms/Nkx3-1⁺; Pten^tm1Rps/Pten⁺
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:75085 )

♂ • early carcinoma lesions are seen in the prostate at 6 months of age

increased prostate intraepithelial neoplasia incidence ( J:75085 )

♂ • at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions

♂ • multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures

♂ • lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index

♂ • lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:75085 )

♂ • early carcinoma lesions are seen in the prostate at 6 months of age

increased prostate intraepithelial neoplasia incidence ( J:75085 )

♂ • at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions

♂ • multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures

♂ • lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index

♂ • lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

reproductive system

increased prostate gland tumor incidence ( J:75085 )

♂ • early carcinoma lesions are seen in the prostate at 6 months of age

increased prostate intraepithelial neoplasia incidence ( J:75085 )

♂ • at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions

♂ • multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures

♂ • lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index

♂ • lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:75085