Phenotypes Associated with This Genotype

Genotype
MGI:5570747

• Allelic Composition: Tg(Slc1a2-tTA)#Waw/0; Tg(tetO-MYCN,-luc)#Waw/0
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:160518 )

• survival is 80% at 100 days of age and 60% at 200 days of age

• adult mice with tumors placed on dox survive through 200 days

neoplasm

increased metastatic potential ( J:160518 )

• a few mutants show disseminated tumor in the lumbrosacral region, partially encasing nerve roots in the subarachnoid spaces adjacent to the spinal cord, indicating spinal metastases

increased malignant tumor incidence ( J:160518 )

• spinal metastases are discontinuous with primary tumors, suggesting leptomeningeal spread through cerebrospinal fluid

increased medulloblastoma incidence ( J:160518 )

• mice develop cerebellar tumors that show histology of classic medulloblastoma and large cell anaplastic medulloblastoma

• classic tumors consist of cells with moderate stromal content, low to intermediate vascularity, and variable anaplasia

• large cell anaplastic tumors have larger cells which show high nuclear-to-cytoplasmic ratios, polygonal cell morphology, and high levels or anaplasia and invasion which disrupts the molecular layer, Purkinje layer, and internal granular layer

• mice placed on doxycycline (dox) at P1 for 30 days do not develop tumors at P200

• acute treatment with dox results in a decrease in apoptotic cells and in cell proliferation in tumors

nervous system

increased medulloblastoma incidence ( J:160518 )

• mice develop cerebellar tumors that show histology of classic medulloblastoma and large cell anaplastic medulloblastoma

• classic tumors consist of cells with moderate stromal content, low to intermediate vascularity, and variable anaplasia

• large cell anaplastic tumors have larger cells which show high nuclear-to-cytoplasmic ratios, polygonal cell morphology, and high levels or anaplasia and invasion which disrupts the molecular layer, Purkinje layer, and internal granular layer

• mice placed on doxycycline (dox) at P1 for 30 days do not develop tumors at P200

• acute treatment with dox results in a decrease in apoptotic cells and in cell proliferation in tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:160518