growth/size/body
• from 5 weeks of age onwards
|
homeostasis/metabolism
• significant increase in male and female from 2 weeks of age onwards
• concentrations increase with age
• levels are higher than in heterozygous mutants and in mice homozygous for Umodurehr4
|
renal/urinary system
|
• at 20-22 months of age, more severe than heterozygous mutants
|
|
• at 20-22 months of age, more severe than heterozygous mutants
|
• elevated plasma cystatin C levels indicate decreased glomerular filtration rate at 4 months of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
kidney disease | DOID:557 | J:201084 |