Phenotypes Associated with This Genotype

Genotype
MGI:5571374

• Allelic Composition: Tg(Igh-ROR1)1Kip/0; Tg(Igh-V186.2-TCL1A)3Cro/0
• Genetic Background: B6.Cg-Tg(Igh-ROR1)1Kip Tg(Igh-V186.2-TCL1A)3Cro

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased chronic lymphocytic leukemia incidence ( J:206368 )

• develop leukemia at a younger median age than mice with either transgene alone

• expansion of CD5+B220^low B cells is accelerated and mice show earlier development of leukemia compared to single Tg(Igh-ROR1)1Kip mice

mortality/aging

premature death ( J:206368 )

• median survival is 50.6 weeks

hematopoietic system

enlarged spleen ( J:206368 )

increased lymphocyte cell number ( J:206368 )

• develop CD5+B220^low B-cell lymphocytosis at a younger median age than mice with either transgene alone

increased mature B cell number ( J:206368 )

• double mutants show an increase in percentage of CD5+B220^low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice

immune system

enlarged spleen ( J:206368 )

increased lymphocyte cell number ( J:206368 )

• develop CD5+B220^low B-cell lymphocytosis at a younger median age than mice with either transgene alone

increased mature B cell number ( J:206368 )

• double mutants show an increase in percentage of CD5+B220^low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice

growth/size/body

enlarged spleen ( J:206368 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:206368