Phenotypes Associated with This Genotype

Genotype
MGI:5572817

• Allelic Composition: Tg(ASL1/Cryaa-Ralbp1)24Yca/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye morphology ( J:210388 )

• retina and cornea are present but their architecture and position are distorted, although this may be due to the small lens

abnormal lens morphology ( J:210388 )

• lens actin cytoskeleton organization is disrupted

• disorganized lens

• the posterior part of lens affects the organization of the neural retina by pulling it inwards

abnormal lens development ( J:210388 )

• marker analysis indicates that lens development is impaired at E16.5

fused cornea and lens ( J:210388 )

• delay in detachment of developing lens from the cornea at the anterior region of the eye

small lens ( J:210388 )

• lens is already smaller at E16.5

microphthalmia ( J:210388 )

• eye weight/body weight ratio is reduced 40-45%

cellular

abnormal actin cytoskeleton morphology ( J:210388 )

• lens actin cytoskeleton organization is disrupted

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
microphthalmia		DOID:10629		J:210388