Phenotypes Associated with This Genotype

Genotype
MGI:5573199

• Allelic Composition: Tg(Thy1-Snca)1S13Putt/0; Uchl1^tm1Dgen/Uchl1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:207278 )

• at 3.5 months of age, mutants need to be sacrificed due to poor health

nervous system

astrocytosis ( J:207278 )

• mice show a large increase in astrogliosis at 3.5 months of age compared to single Tg(Thy1-Snca)1S13Putt mutants, especially in the cortex and to a lesser extent in the hippocampus and the striatum, but not in the cerebellum, brainstem, and thalamus

• 3.5 month old mice however, do not show microgliosis or axon degeneration

alpha-synuclein inclusion body ( J:207278 )

• increase in perikaryal alpha-synuclein accumulation in the cell soma of hippocampal neurons at 3.5 months of age

behavior/neurological

impaired coordination ( J:207278 )

• mice show greater deficits in motor coordination on the rotarod than single Uchl1 homozygotes at 2.5 months of age

decreased grip strength ( J:207278 )

• mice show greater deficits in muscle strength than single Uchl1 homozygotes at 2.5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:207278