Phenotypes Associated with This Genotype

Genotype
MGI:5574086

• Allelic Composition: Kcna10^tm1Lex/Kcna10^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:210785 )

N • mice do not exhibit circling behavior or overt balance problems

increased or absent threshold for auditory brainstem response ( J:210785 )

• mild

abnormal linear vestibular evoked potential ( J:210785 )

• as early as P30 with poorly formed waveforms and broad response peaks

• elevated threshold at 10 months

absent linear vestibular evoked potential ( J:210785 )

• in 3 of 6 mice at P30

• in 3 of 8 mice at 10 months

behavior/neurological

behavior/neurological phenotype ( J:210785 )

N • mice do not exhibit circling behavior or overt balance problems

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
vestibular disease		DOID:3426		J:210785