Phenotypes Associated with This Genotype

Genotype
MGI:5576517

• Allelic Composition: Tg(Wap-Hgf)402Mig/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:86776 )

♀ • 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies

♀ • 10 of 50 virgin females develop one or multiple tumors before 1 year of age

♀ • tumors have a complex glandular and squamous pattern with extensive necrosis

♀ • tumors show malignancy markers

♀ • profuse squamous metaplasia in tumors and lung metastasis

increased mammary gland tumor incidence in breeding females ( J:86776 )

♀ • 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies

♀ • most females develop multi-focal tumors in more than one gland after several pregnancies

increased mammary gland tumor incidence in virgin females ( J:86776 )

♀ • 10 of 50 virgin females develop one or multiple tumors before 1 year of age

increased metastatic potential ( J:86776 )

♀ • 12 of 55 females show lung metastases

endocrine/exocrine glands

abnormal mammary gland morphology ( J:86776 )

♀ • a thick layer of fibroblasts surround the mammary epithelium in virgin females

abnormal branching of the mammary ductal tree ( J:86776 )

♀ • mammary ductal trees of virgin females have an altered morphology characterized by abundant lobular structures protruding from ducts resembling aborted branches covering the ductal surface

mammary gland duct hyperplasia ( J:86776 )

♀ • virgin females exhibit hyperplastic ductal trees

♀ • hyperplastic ductal trees are seen upon involution

increased mammary adenocarcinoma incidence ( J:86776 )

♀ • 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies

♀ • 10 of 50 virgin females develop one or multiple tumors before 1 year of age

♀ • tumors have a complex glandular and squamous pattern with extensive necrosis

♀ • tumors show malignancy markers

♀ • profuse squamous metaplasia in tumors and lung metastasis

increased mammary gland tumor incidence in breeding females ( J:86776 )

♀ • 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies

♀ • most females develop multi-focal tumors in more than one gland after several pregnancies

increased mammary gland tumor incidence in virgin females ( J:86776 )

♀ • 10 of 50 virgin females develop one or multiple tumors before 1 year of age

integument

abnormal mammary gland morphology ( J:86776 )

♀ • a thick layer of fibroblasts surround the mammary epithelium in virgin females

abnormal branching of the mammary ductal tree ( J:86776 )

♀ • mammary ductal trees of virgin females have an altered morphology characterized by abundant lobular structures protruding from ducts resembling aborted branches covering the ductal surface

mammary gland duct hyperplasia ( J:86776 )

♀ • virgin females exhibit hyperplastic ductal trees

♀ • hyperplastic ductal trees are seen upon involution

increased mammary adenocarcinoma incidence ( J:86776 )

♀ • 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies

♀ • 10 of 50 virgin females develop one or multiple tumors before 1 year of age

♀ • tumors have a complex glandular and squamous pattern with extensive necrosis

♀ • tumors show malignancy markers

♀ • profuse squamous metaplasia in tumors and lung metastasis

increased mammary gland tumor incidence in breeding females ( J:86776 )

♀ • 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies

♀ • most females develop multi-focal tumors in more than one gland after several pregnancies

increased mammary gland tumor incidence in virgin females ( J:86776 )

♀ • 10 of 50 virgin females develop one or multiple tumors before 1 year of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:86776