Phenotypes Associated with This Genotype

Genotype
MGI:5576527

hm1

• Allelic Composition: Trp63^tm2.2Elrf/Trp63^tm2.2Elrf
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:206433 )

• although born in a normal Mendelian ratio, all die within hours of birth

integument

abnormal epidermal layer morphology ( J:206433 )

• rudimentary stratified epithelium

• hyperproliferative epidermis

• colonies of epidermal cells in culture remain proliferative much longer, incorporating BrdU at high levels even at passage 5

abnormal epidermis stratum basale morphology ( J:206433 )

• expanded basal layer

• nests of basal epithelium in patches covering 20-30% of embryo

abnormal epidermis stratum spinosum morphology ( J:206433 )

• expanded spinous layer

dermal-epidermal separation ( J:206433 )

• fragile epidermis is easily detached from the dermis