Phenotypes Associated with This Genotype

Genotype
MGI:5578176

• Allelic Composition: Tg(HBV-HCV)Kko/0
• Genetic Background: C57BL/6N-Tg(HBV-HCV)Kko

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial inner membrane morphology ( J:52686 , J:69727 )

♂ • disappearance of the double structure of mitochondrial membranes in the liver (J:52686)

♂ • disruption of the double structure of the mitochondrial membrane from liver mitochondria (J:69727)

oxidative stress ( J:69727 )

♂ • intracellular increase in lipid peroxidization in the liver as showed by an increase in hydroperoxide products indicating oxidative stress in the liver in the absence of inflammation

liver/biliary system

abnormal hepatocyte morphology ( J:69727 )

♂ • hepatocytes from 12 month or older mice exhibit scattered residual bodies or lipofuscin granules and secondary lysosomes carrying various cytoplasmic organelles, indicating signs of damage induced by reactive oxygen species

hepatic steatosis ( J:52686 , J:94426 )

♂ • mild steatosis at young age that becomes moderate to severe with increasing age (J:52686)

♂ • all males and about 50% of females develop steatosis by 6 months of age (J:52686)

♂ • however, mice show normal weight and total cholesterol and triglyceride levels (J:52686)

increased hepatocellular carcinoma incidence ( J:52686 )

♂ • hepatocellular carcinoma develops from within the adenomas without cytoplasmic fat droplets

increased liver adenoma incidence ( J:52686 )

♂ • male mice develop hepatic tumors after 16 months of age that first appear as adenomas containing fat droplets in the cytoplasm

abnormal liver physiology ( J:69727 )

♂ • intracellular increase in lipid peroxidization in the liver as indicated by an increase in hydroperoxide products by about 170% compared to controls

♂ • administration of alcohol causes an increase in the levels of hydroperoxides of phosphatidylcholine

neoplasm

increased hepatocellular carcinoma incidence ( J:52686 )

♂ • hepatocellular carcinoma develops from within the adenomas without cytoplasmic fat droplets

increased liver adenoma incidence ( J:52686 )

♂ • male mice develop hepatic tumors after 16 months of age that first appear as adenomas containing fat droplets in the cytoplasm

homeostasis/metabolism

decreased glutathione level ( J:69727 )

♂ • total and reduced glutathione level is lower than in controls

increased catalase activity ( J:69727 )

♂ • males show an increase in catalase activity in the liver

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:69727