Analysis Tools
homeostasis/metabolism
| N |
• mice exhibit normal plasma ACTH, adiponectin and phosphate levels
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• overt diabetes mellitus in most mice
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• in female, but not male, mice
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• in female, but not male, mice
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• in fasted mice at 8, 12 and 16 weeks
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• at 12 weeks in female and male mice
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• in female and male mice at 8 to 12 weeks
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• in 24 week old mice after a 4-hour fast
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• in 24 week old mice after a 4-hour fast
|
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• in female and male mice at 8 to 12 weeks
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• mild in female and male
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• in female and male
|
 |
• in male, but not female, mice
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• in female, but not male, mice
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• by 19 weeks with frustosamine concentrations
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• in fasted female and male mice at 8 weeks
• persisting at 12 and 16 weeks
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• likely insulin resistance due to increased adiposity
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• diminution of corticosterone circadian rhythm
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• in female and male mice
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• peak concentration is 8-fold greater than the nadir value
|
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• in female, but not male, mice
|
skeleton
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• increased adipocytes in the bone marrow
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• with reduced percentage of corticoendosteal bone covered by osteoblasts
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• reduced mineralization surface area
• reduced mineral apposition rates
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• reduced bone formation rates
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growth/size/body
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• from 5 weeks in female and male mice
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• in male mice only at 5 weeks
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• in female mice from 6 weeks on
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renal/urinary system
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• in female and male mice
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• peak concentration is 8-fold greater than the nadir value
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• in female, but not male, mice
|
behavior/neurological
polydipsia
(
J:208708
)
|
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• in male, but not female, mice
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liver/biliary system
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• moderate diffuse microvesicular vacuolation
|
adipose tissue
|
• from 5 weeks in female and male mice
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• increased adipocytes in the bone marrow
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endocrine/exocrine glands
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• hypertrophic
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• increased weight
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integument
limbs/digits/tail
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| primary hyperaldosteronism | DOID:446 |
OMIM:605635 OMIM:613677 |
J:208708 | |
