Phenotypes Associated with This Genotype

Genotype
MGI:5581429

• Allelic Composition: Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:210074 )

• at 6 and 12-14 months of age, but not 3 months, mice do not distinguish between old and new objects in the object recognition test, exploring the new and familiar object equally

impaired spatial learning ( J:210074 )

• during the acquisition phase of the Morris water maze, 12 month old mutants do not learn as well as wild-type mice

• during the probe phase of the Morris water maze, 3, 6, and 12-14 month old mice are unable to remember the target quadrant

homeostasis/metabolism

amyloid beta deposits ( J:210074 )

• amyloid beta immunoreactive dystrophic neurites in the hippocampus are first seen at 3 months of age and in the neocortex at 12-14 months of age

nervous system

amyloid beta deposits ( J:210074 )

• amyloid beta immunoreactive dystrophic neurites in the hippocampus are first seen at 3 months of age and in the neocortex at 12-14 months of age

tau protein deposits ( J:210074 )

• phosphorylated tau is seen in neurons of the lateral entorhinal cortex at 3 months of age, with a prominent somatodendritic location, and spreads to neurons of other cortical and hippocampal regions with age

abnormal cholinergic neuron morphology ( J:210074 )

• decrease in the number of ChAT-positive neurons in the nucleus basalis of Meynert at 6 and 12-14 months of age and in the medial septum/diagonal band of Broca at 3, 6, and 12-14 months

neuron degeneration ( J:210074 )

• degeneration of cholinergic neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:210074