Phenotypes Associated with This Genotype

Genotype
MGI:5581681

• Allelic Composition: App^tm1Ck/App^tm1Ck; Psen1^tm1Mpm/Psen1^tm1Mpm; Tg(MAPT)8cPdav/0
• Genetic Background: B6.Cg-Tg(MAPT)8cPdav Psen1^tm1Mpm App^tm1Ck

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced contextual conditioning behavior ( J:209782 )

• mice show increased contextual freezing frequency at 4 and 12 months of age

• however, cued freezing frequency is unaffected and mice do not exhibit spatial memory deficits in the Morris water maze

increased anxiety-related response ( J:209782 )

• in the elevated plus maze, 4 month old mice spend less time on the open arm, indicating increased anxiety

• however, mice show normal nociception in the hot plate assay

increased fear-related response ( J:209782 )

• mice show slightly higher pre-shock freezing frequency and increased contextual freezing frequency at 4 and 12 months of age, indicating exaggerated fear response

decreased locomotor activity ( J:209782 )

• in the open field, the total travel distance is reduced at 12, but not 4, months of age, indicating age-dependent reduced activity

homeostasis/metabolism

amyloid beta deposits ( J:209782 )

• mice exhibit amyloid beta plaques on the outer edge of the cortex at 18-22 months of age which progress into inner layers of the cortex and hippocampus by 26-29 months of age

nervous system

amyloid beta deposits ( J:209782 )

• mice exhibit amyloid beta plaques on the outer edge of the cortex at 18-22 months of age which progress into inner layers of the cortex and hippocampus by 26-29 months of age

tau protein deposits ( J:209782 )

• increase in phosphorylated tau in the cortex and hippocampus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:209782