About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5581715
cx18
Allelic
Composition		 Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (9 available); any Il6 mutation (38 available)
Ncoa5tm1Hxia mutation (0 available); any Ncoa5 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocellular carcinoma incidence ( J:207622 )
• fewer and smaller maximum tumor volume than in Ncoa5tm1Hxia male heterozygotes

reproductive system
reproductive system phenotype ( J:207622 )
N
• unlike Ncoa5tm1Hxia male heterozygotes, male mice are fertile

neoplasm
increased hepatocellular carcinoma incidence ( J:207622 )
• fewer and smaller maximum tumor volume than in Ncoa5tm1Hxia male heterozygotes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:207622 )
N
• unlike Ncoa5tm1Hxia male heterozygotes, male mice exhibit normal circulating glucose levels, glucose tolerance and insulin sensitivity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory