Phenotypes for Hbb-b1 Hbb-b2 MGI:5582253 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hbb-b1^tm1Unc/Hbb-b1⁺ Hbb-b2^tm1Unc/Hbb-b2⁺
Genetic Background	B6;129-Hbb-b1^tm1Unc Hbb-b2^tm1Unc/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1^tm1Unc mutation (2 available); any Hbb-b1 mutation (7 available)
Hbb-b2^tm1Unc mutation (2 available); any Hbb-b2 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:211331 )

abnormal spleen morphology ( J:211331 )

• Fam123b mRNA levels are increased by 16-fold in the spleen

homeostasis/metabolism

increased circulating erythropoietin level ( J:211331 )

• very high serum erythropoietin concentrations

immune system

abnormal spleen morphology ( J:211331 )

• Fam123b mRNA levels are increased by 16-fold in the spleen

skeleton

abnormal bone marrow morphology ( J:211331 )

• Fam123b mRNA levels are increased by 10-fold in the bone marrow

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:211331

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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