Phenotypes Associated with This Genotype

Genotype
MGI:5582588

• Allelic Composition: Tg(H2-K-IL6)2Srj/0
• Genetic Background: B6.Cg-Tg(H2-K-IL6)2Srj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:185153 )

• 15 week old mice exhibit enlarged spleen

abnormal definitive hematopoiesis ( J:185153 )

• 28% of mice exhibit multicentric Castleman disease-like changes

extramedullary hematopoiesis ( J:185153 )

• 32% of mice exhibit increased extramedullary hematopoiesis

increased megakaryocyte cell number ( J:185153 )

• elevation in numbers of megakaryocytes in the spleen of 15 week old mice

abnormal granulocyte morphology ( J:185153 )

• increase in granulocytopoiesis in the spleen in 15 week old mice

increased plasma cell number ( J:185153 )

• 44% of mice exhibit plasmacytosis in the red pulp of the spleen

• massive accumulations of plasma cells in peripheral lymph nodes

abnormal spleen red pulp morphology ( J:185153 )

• red pulp of spleen shows increased proliferation

abnormal spleen germinal center morphology ( J:185153 )

• hyperplastic germinal centers in 15 week old mice

increased IgG level ( J:185153 )

• 4-fold elevation in serum levels of IgG

immune system

enlarged spleen ( J:185153 )

• 15 week old mice exhibit enlarged spleen

abnormal granulocyte morphology ( J:185153 )

• increase in granulocytopoiesis in the spleen in 15 week old mice

increased plasma cell number ( J:185153 )

• 44% of mice exhibit plasmacytosis in the red pulp of the spleen

• massive accumulations of plasma cells in peripheral lymph nodes

abnormal spleen red pulp morphology ( J:185153 )

• red pulp of spleen shows increased proliferation

abnormal spleen germinal center morphology ( J:185153 )

• hyperplastic germinal centers in 15 week old mice

increased IgG level ( J:185153 )

• 4-fold elevation in serum levels of IgG

abnormal lymph node morphology ( J:185153 )

• enlarged B-cell follicles in peripheral and deep abdominal lymph nodes that contain hyperplastic germinal centers and vascular proliferation and massive accumulations of plasma cells

abnormal lymph node germinal center morphology ( J:185153 )

• hyperplastic germinal centers in 15 week old mice

enlarged lymph nodes ( J:185153 )

• 15 week old mice exhibit enlarged lymph nodes

growth/size/body

enlarged spleen ( J:185153 )

• 15 week old mice exhibit enlarged spleen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
viral infectious disease		DOID:934		J:185153